SYNTHETIC IMMUNOLOGY

We investigate how cell-cell interactions shape the immune response by combining chemical and synthetic biology with immunology and mouse genetics.

RESEARCH

Interactions between different cell types are key for immune function. Nevertheless, our toolbox to observe and decipher the biological meaning of interactions between immune cells in living animals is very limited. By coupling chemical and synthetic biology with mouse genetics, research in the Synthetic Immunology Lab aims at developing innovative technologies to study cell-cell communication in the immune system. We use these novel experimental approaches to track interactions between antigen-presenting cells and T cells, with the ultimate goal of revealing the molecular pathways governing the T cell response in vivo.

 
 

MEMBERS

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Principal Investigator
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MADDALENA ELIA
Research Associate
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AGNIESZKA MACIOLA
Postdoctoral Associate
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MICHELLE GUARNIERO
Research Associate
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DAFNE ALBERTI
Master Student
 

SELECTED PUBLICATIONS

Chudnovskiy A, Pasqual G, Victora GD (2019) Studying interactions between dendritic cells and T cell in vivo. Current Opinion in Immunology 58:24-30.

Pasqual G, Chudnovskiy A, Tas JM, Schweitzer LD, Cui A, Agudelo M, Hacohen N, Victora GD (2018) Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labeling. Nature 553:496-500.

Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD (2017) Germinal center selection and affinity maturation require dynamic regulation of mTORC1. Immunity 46:1045-1058.

Tas JM, Mesin L, Pasqual G, Targ S, Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M, Victora GD (2016) Visualizing affinity maturation in germinal centers. Science 351:1048-1054. 

Shulman Z, Gitlin AD, Targ S, Jankovic M, Pasqual G, Nussenzweig MC, Victora GD (2013) T follicular helper cell dynamics in germinal genters. Science 341:673-677.

NEWS

 

Morning experiment: picture for the press

We have been awarded the European Research Council Starting Grant

 

CONTACT

Giulia Pasqual, Associate Professor
Department Of Surgery Oncology and Gastroenterology
Università degli Studi di Padova
via Gattamelata 64
35128 Padova PD Italy
+39 049 8215891
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