We investigate how cell-cell interactions shape the immune response by combining chemical and synthetic biology with immunology and mouse genetics.
Interactions between different cell types are key for immune function. Nevertheless, our toolbox to observe and decipher the biological meaning of interactions between immune cells in living animals is very limited. By coupling chemical and synthetic biology with mouse genetics, research in the Synthetic Immunology Lab aims at developing innovative technologies to study cell-cell communication in the immune system. We use these novel experimental approaches to track interactions between antigen-presenting cells and T cells, with the ultimate goal of revealing the molecular pathways governing the T cell response in vivo.